https://www.breakingdownbio.com/breakingdownbioblog daily 1.0 2026-02-27 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/9c666f2c-d683-46b6-948d-b5158da840be/BDB+Logo.png https://www.breakingdownbio.com/breakingdownbioblog/when-diseases-travel-together-insights-from-endometriosis-patients monthly 0.5 2026-02-27 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1a01710e-f65d-44f3-80c4-739bc0c95c93/Hung_BDB+Schematic.png Blog - When Diseases Travel Together: Insights from Endometriosis Patients - Khan et al. analyzed one of the largest collections of health records from endometriosis to date, with patients drawn from several University of California databases, including a separate database from the University of California, San Francisco. In doing so, they found several comorbidities that occurred more frequently in endometriosis patients than in matched healthy controls. This was supported not only by prior literature but also by an orthogonal approach that identified patient subgroups characterized by many of the same comorbidities. https://www.breakingdownbio.com/breakingdownbioblog/gut-microbes-peanut-allergy monthly 0.5 2026-01-31 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/7d6c54bb-1e21-46b1-94c8-85f8672278f2/BDB+Blog+2+Schema+1.png Blog - Are Gut Microbes “Eating” Your Peanut Allergy Treatment? - This study provides a more comprehensive and in-depth secondary analysis of the IMPACT clinical trial that was published in 2022. In the IMPACT trial, children aged 1 to 4 years old who were allergic to peanuts were randomly treated with either POIT (peanut) or a placebo (oat flour). For two years, the researchers collected their stool (poop) samples at five different time points, from before the treatment to weeks after ending the treatment. In this way, they created a “history book” of the gut microbiome along the progression of POIT (Jones et al., 2022). The study from the Lynch Lab read this “book” and mainly focused on poop samples from the POIT-treated children, using various advanced methods to analyze the bacteria found within. https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/4200f689-e979-4381-a040-b6863279c25b/BDB+Blog+2+Schema+2+%281%29.png Blog - Are Gut Microbes “Eating” Your Peanut Allergy Treatment? - Bile acids are chemicals that help with fat digestion. They are first produced in the liver and then transported to the gut, playing a crucial role in breaking down the hamburger one might just have for lunch. Surprisingly, the study discovers that they are also associated with responses to POIT. The level of bile acid in the gut before the treatment may be used to predict whether the patient will achieve remission. Or, in other words, whether the treatment effect can last after POIT ends. https://www.breakingdownbio.com/breakingdownbioblog/bladder-cancer-variants monthly 0.5 2026-01-31 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/c59759ef-42a9-4174-b760-9a7952b97062/Wendy+Xu_Schematic.png Blog - Bladder cancer variants share aggressive cell state and gene expression features - RNA is collected from individual cells of tumor tissue. The RNA is then labelled and sequenced, with sequencing data converted into graphs to visualize similarities and differences in gene expression. https://www.breakingdownbio.com/breakingdownbioblog/dna-methylation-profiles-and-placental-malaria monthly 0.5 2026-01-16 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/c1e5ec40-9a54-4d54-9cc3-74a5c52151b9/Lozano_DNA+Methylation.png Blog - DNA Methylation Profiles and Placental Malaria De novo DNA methylation is the process by which new DNA methylation patterns are established on previously unmethylated DNA. It occurs when the enzymes DNMT3A and DNMT3B add a new methyl group to cytosine, converting the compound into 5-methylcytosine (5mC). Demethylation, on the other hand, describes the removal of methyl groups from cytosine, occurring either actively through the involvement of TDG and TET enzymes or passively due to a lack of DNMT1, an enzyme responsible for maintaining methylation on a 5mC compound. https://www.breakingdownbio.com/breakingdownbioblog/hemoglobinopathies monthly 0.5 2026-01-08 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/35047ee4-aaed-4d28-be71-a359e4d79988/Sharma_Schematic.png Blog - Investigating In Utero Treatments of Hemoglobinopathies - Researchers injected LNPs in fetal mice to target HSCs found in the liver during this developmental period. Their goal was to deliver genome editors and monitor the genetic changes in HSCs. https://www.breakingdownbio.com/breakingdownbioblog/hiv-and-obesity-related-sat-fibrosis monthly 0.5 2026-01-08 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/6bff0a12-993d-4868-a018-6df9f32e9d64/SAT+Fibrosis+2.png Blog - The Distinction between HIV and Obesity Related SAT Fibrosis - Subcutaneous adipose tissue (SAT) fibrosis is the buildup of fibrous tissue around fat cells under the skin. Common in obesity, this scarring can limit healthy fat storage and is linked to insulin resistance. Because people living with HIV have higher rates of metabolic complications, this figure compares healthy SAT, obesity-associated SAT fibrosis, and HIV-associated SAT fibrosis—illustrating how normal, round adipocytes become surrounded by thick collagen in obesity and replaced by dense fibrotic tissue in HIV. https://www.breakingdownbio.com/breakingdownbioblog/tracing-maternal-hyperglycemia monthly 0.5 2025-11-24 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/d8fdec1c-080a-4c94-be6a-af0b3e36fee8/Screenshot+2025-11-14+at+10.15.11%E2%80%AFAM.png Blog - Tracing the Impact of Maternal Hyperglycemia on Fetal Development - Researchers used Akita mice, a Type 1 diabetes model, to study how high blood sugar in pregnancy affects fetal development. After fasting, pregnant mice received U-¹³C glucose so the team could trace how glucose was metabolized in both mother and fetus. https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/57643070-797f-4aeb-9740-a5a55323c20e/Screenshot+2025-11-14+at+10.22.14%E2%80%AFAM.png Blog - Tracing the Impact of Maternal Hyperglycemia on Fetal Development - LC-MS is a two-step technique. In step one, namely liquid chromatography, the metabolite soup that researchers extracted from the fetal tissue is separated based on its chemical properties. The second step in LC-MS, mass spectrometry, measured the mass-to-charge ratio of each metabolite by ionizing metabolite particles and accelerating them through an electromagnetic field. This step tells researchers three things: the metabolite’s identity, how much of it is present, and whether or not it was tagged by ¹³C. https://www.breakingdownbio.com/breakingdownbioblog/cracking-the-code-glial-signaling monthly 0.5 2025-11-14 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/c494c606-7c56-42cf-a782-35d7e686adca/Schema+3.jpeg Blog - Cracking the Code: How Glial Signaling Shakes the Barrier - Here in this schema, we see that Radial Glial Cells that are healthy in functioning, help construct a very strong Blood Brain Barrier. However, in cases where Radial Glial Cells are mutated and dysfunctional, a leaky Blood Brain Barrier is caused, resulting in cerebral small vessel diseases such as CADASIL. https://www.breakingdownbio.com/breakingdownbioblog/microbiota-capecitabine monthly 0.5 2025-11-24 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/3611055d-9e88-4851-8fc7-f3af0ae77e34/Scarlett+BDB+Image.png Blog - How to Use Gut Bacteria to Make Chemo Safer - Capecitabine, a chemotherapy drug, changes the gut microbiome (the ecosystem of microbes in the gut). It is found to increase the number of vitamin K2-producing E.coli (a type of bacteria), which may be associated with protecting the gut microbiome and relieving chemotherapy side effects.. https://www.breakingdownbio.com/breakingdownbioblog/exercise-ctd-pah monthly 0.5 2025-10-10 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/b777fa99-0478-4cdb-8a57-a2105d978150/Lexi+BDB+Image.png Blog - Uncovering the Impact of Exercise on Pulmonary Vascular Metabolism - Diagram showing simultaneous blood collection from the pulmonary artery and radial artery during one of four stages of physical activity. Plasma from both sites is collected into separate containers. The plasma is then tested for metabolites and other information. Diagram showing simultaneous blood collection from the pulmonary artery and radial artery during one of four stages of physical activity. Plasma from both sites is collected into separate containers. The plasma is then tested for metabolites and other information. https://www.breakingdownbio.com/breakingdownbioblog/behind-the-high-how-chronic-cannabis-use-affects-your-vessels monthly 0.5 2025-11-24 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/658b1c5a-3dac-4988-a5a8-f6c4c50b4e3a/SR_BDB+Image.png Blog - Behind the High: How Chronic Cannabis Use Affects Your Vessels - An infographic titled “Impact of Chronic Cannabis Use on Vascular Health” shows three blood vessels side by side: An infographic titled “Impact of Chronic Cannabis Use on Vascular Health” shows three blood vessels side by side. None (baseline/healthy): The first vessel is wide with many healthy red blood cells flowing smoothly, representing normal endothelial function and vascular health. Occasional: The second vessel remains open with red blood cells flowing, showing no detectable long-term dysfunction from occasional cannabis use. Frequent: The third vessel is narrowed with fewer red blood cells passing through, illustrating endothelial dysfunction and impaired vascular health associated with chronic cannabis use. The caption at the bottom notes: “Cannabis Smoking and THC-Edible Use Frequency.” https://www.breakingdownbio.com/breakingdownbioblog/biotimerpregnancy monthly 0.5 2025-08-26 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/35d65024-b136-4d77-99bd-8314ed05ad35/Ali+BDB+Schematic.png Blog - Due Dates: How a Molecular Timer May Set the Start of Labor - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.breakingdownbio.com/breakingdownbioblog/4x1x919xjq6yguvjldauymsv7ucqub monthly 0.5 2024-09-29 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/97daa858-4c50-4fe4-acab-4baac080f6b6/Highmagstream.png Blog - The Journey of Migrating Neurons in the Temporal Lobe: the long road home - Make it stand out Migrating neurons in the human brain. https://www.breakingdownbio.com/breakingdownbioblog/structural-and-molecular-basis-of-choline-uptake-into-the-brain-by-flvcr2 monthly 0.5 2024-09-06 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/7f67651e-75d0-40a0-8b9a-5ff68bed364e/Screenshot+2024-07-31+at+9.43.15+AM.png Blog - Structural and molecular basis of choline uptake into the brain by FLVCR2 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/bb08756c-7ff7-41bf-8a21-9ab3caf985ad/BBB+is+a+choline+transporter+%281%29+%281%29+%281%29.png Blog - Structural and molecular basis of choline uptake into the brain by FLVCR2 - Make it stand out Figure legend: Choline uptake in the brain by FLVCR2 in endothelial cells. https://www.breakingdownbio.com/breakingdownbioblog/fkceoswavzwsrb8328dre9ki3iuugl monthly 0.5 2024-08-05 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/263dee5b-fdc5-4847-9a45-2e8e830549ee/Untitled.jpg Blog - Dynamic Detection: Real-Time Brain Hypoxia Imaging - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.breakingdownbio.com/breakingdownbioblog/brain-fog-in-covid-19-a-detailed-look monthly 0.5 2024-07-21 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/5e4b523c-a091-445c-a9f4-e2f50f72927a/BBB+%282%29.jpg Blog - Brain Fog in COVID-19: A Detailed Look - Make it stand out Figure: The image shows a castle representing the brain, surrounded by a thick protective wall labeled "Blood-Brain Barrier (BBB)". The wall has cracks, symbolizing its vulnerability. Researchers in lab coats are working on repairing the wall and analyzing data on computer screens. The floating brains, DNA helices, viruses, and a syringe add to the scientific context. The image symbolizes the brain's protection, the impact of vulnerabilities, and ongoing scientific efforts to repair and understand the BBB. https://www.breakingdownbio.com/breakingdownbioblog/stroke-recovery-revolution-the-effect-of-mscs-mscepo-and-epo3-on-arterial-ischemic-stroke-induced-rodents monthly 0.5 2024-07-19 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/582dd719-296a-4ae1-a849-4ff7c498cfa7/biorender.png Blog - Stroke Recovery Revolution: The Effect of MSCs, MSC/EPO, and EPO3 on Arterial Ischemic Stroke Induced Rodents - Make it stand out Figure: The combinatorial effects of MSCs and erythropoetin (EPO) after neonatal stroke. https://www.breakingdownbio.com/breakingdownbioblog/microscopic-influencers-how-notch1-inspires-tostick-together monthly 0.5 2024-06-22 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/2ca21d7b-d918-47f1-b7e9-c5ab27dda752/BreakingDownBioRender.png Blog - Microscopic Influencers: How Notch1 Inspires to“Stick” Together - Make it stand out Figure: How cortical Notch1 regulates cell shape and adherens junctions. https://www.breakingdownbio.com/breakingdownbioblog/uncovering-the-dual-role-of-astrocytes-and-neurons-in-ocd-pathogenesis monthly 0.5 2024-06-05 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/a352ad8a-9f24-41d6-9c81-afb29f03b2b6/Screenshot+2024-06-04+at+5.22.45+PM.png Blog - A dynamic duo: uncovering the Dual Role of Astrocytes and Neurons in OCD Pathogenesis - Make it stand out Summary of the findings and technical advances from this paper. https://www.breakingdownbio.com/breakingdownbioblog/interferon-driven-neural-circuit-navigators monthly 0.5 2024-05-19 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/b4501c61-d21c-4986-95ed-21b4e2e1aed5/Screenshot+2024-05-19+at+8.02.25+AM.png Blog - Interferon-Driven Neural Circuit Navigators - Make it stand out Schema representing the main findings of the paper. https://www.breakingdownbio.com/breakingdownbioblog/unraveling-the-gendered-threads-of-brain-aging-insights-from-angiogenesis-markers monthly 0.5 2024-04-16 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/5dfc8046-4ddc-422c-a690-d91cf00814ab/Dr.+Crouch+Schema+1.jpeg Blog - Unraveling the Gendered Threads of Brain Aging: Insights from Angiogenesis Markers - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.breakingdownbio.com/breakingdownbioblog/bmcy3lmeapo797vxnylzr2tjsq22hw monthly 0.5 2021-02-22 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1613877840736-YJPCLOOUBJPIDHVBQKAI/Picture1.png Blog - Autoantibodies help prevent a broken heart https://www.breakingdownbio.com/breakingdownbioblog/0zqxxzbgedrgeen4zogcs23w17dtot monthly 0.5 2021-02-18 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1613671109066-HJUY4IGBTEV4LYCD5ONG/Picture1.png Blog - Dendritic Cells Actin’ Out Fluorescence microscopy images of synapses formed between mature WT or hem1-deficient DCs and T cells stained with phalloidin (red) and DAPI (blue). Scale bar: 5 µm. https://www.breakingdownbio.com/breakingdownbioblog/uurklnnjeu1wcajpqzc5vne88qyv2u monthly 0.5 2021-01-30 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1611971087624-PCPHWDHP9TFD5HZIF282/Screen+Shot+2021-01-29+at+5.43.03+PM.png Blog - Memory B cells with a flavour for flaviviruses https://www.breakingdownbio.com/breakingdownbioblog/lung-cellular-senescence-in-covid-19 monthly 0.5 2020-12-25 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1608845517917-ZVKN8Q3ZJN81L3Z4RCZ0/fibrosis+via+cellular+scenescence%3F-2.png Blog - Lung cellular senescence in COVID-19 Summary schema of Bharat et al describing the possible role of epithelial cell senescence in COVID-19-associated lung injury. https://www.breakingdownbio.com/breakingdownbioblog/t50n7hv78mrmxju6dc2wp54ranruqu monthly 0.5 2020-10-21 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1603137186424-RODET07HZK65YKHDMY03/Screen+Shot+2020-10-18+at+9.17.41+PM.png Blog - Antibodies interfere with our memories of malaria  https://www.breakingdownbio.com/breakingdownbioblog/keeping-in-check-neuropilin-1-for-effective-antitumor-therapy monthly 0.5 2020-08-14 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1597364661098-1P7DLBMLEUS7MHLSZF8S/Picture1.png Blog - Keeping in Check Neuropilin-1 for Effective Antitumor Therapy Ribbon Diagram of the Crystal Structure of the b1 domain of Human Neuropilin-1, a memory checkpoint for CD8+ T cells in antitumor immunity (Source: Wikipedia) https://www.breakingdownbio.com/breakingdownbioblog/ga52sz0327cm69zeujehgk8bbr3x2m monthly 0.5 2020-07-15 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1594783208810-GMJ02NY6CST88VSJ4SVZ/Screen+Shot+2020-07-14+at+8.19.51+PM.png Blog - Mighty mouth: the gut-mouth axis in treating GI diseases Schema depicting the different connections between bacteria and the immune system in the mouth-gut axis. From the primary paper, Kitamoto et al. https://www.breakingdownbio.com/breakingdownbioblog/jlivfl6gv1ropnq634b4ukzd9umyia monthly 0.5 2020-07-15 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1594777701678-H2SGIPNVUESMUAFNA3GB/Picture1.png Blog - Escaping a universal flu vaccine Adapted from Frontiers in Science https://www.breakingdownbio.com/breakingdownbioblog/6cqgj6jpxzdd428mqcbqxy6p9710uv monthly 0.5 2020-07-15 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1594738673173-CSRD8N9T90WIL9QOFDEV/Screen+Shot+2020-07-14+at+7.57.19+AM.png Blog - Preventing Death: An old Drug Repurposed Schema showing how disulfiram interrupts the inflammatory cascade. Illustration: Boston Children's https://www.breakingdownbio.com/breakingdownbioblog/izc4x0f3la1jvtt9ykn7qjkf4b67dv monthly 0.5 2020-07-12 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1594515524915-DU7PTWKMKOQAF4Y568DL/superbat.jpg Blog - BAT SUPER IMMUNITY https://www.breakingdownbio.com/breakingdownbioblog/the-gift-of-immune-ammunition-convalescent-plasma-for-covid-19 monthly 0.5 2020-07-01 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1593538389222-071ISCM1CO1EDYQ7LCSN/Screen+Shot+2020-06-30+at+10.25.13+AM.png Blog - The gift of immune ammunition: convalescent plasma for COVID-19 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1593538517406-OPKIJCEVR7WZG0Z3TY1I/Screen+Shot+2020-06-30+at+10.35.01+AM.png Blog - The gift of immune ammunition: convalescent plasma for COVID-19 https://www.breakingdownbio.com/breakingdownbioblog/ige-wars-a-neu-hope monthly 0.5 2020-06-27 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1593215878686-DZR3YZY9E3J9HWXIL1MQ/Screen+Shot+2020-06-26+at+4.54.32+PM.png Blog - IgE Wars: A NEU Hope IgE Wars: A NEU Hope. https://www.breakingdownbio.com/breakingdownbioblog/rsv-and-igf1r-more-than-just-a-scratch-on-the-cell-surfacenbsp monthly 0.5 2020-06-22 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1592779109736-YJRREK0ZK99C3S6J23I1/Picture1.png Blog - RSV and IGF1R: More than just a scratch on the “cell” surface  Schematic showing the binding of RSV to its receptor (IGF1R) and subsequent recruitment of its coreceptor (NCL) – from Griffiths et al. Nature 2020 https://www.breakingdownbio.com/breakingdownbioblog/an-expected-source-of-neutrophils-in-covid19 monthly 0.5 2020-06-11 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1591839571827-GLGGBDP0QFRTPNV8C1DA/Screen+Shot+2020-06-10+at+6.39.25+PM.png Blog - An expected source of neutrophils in Covid19 On the left, RNA velocity analysis from Wilk et al showing plasmablasts giving rise to developing neutrophils in COVID19+ patients. On the right, a traditional understanding of immune cell lineage, from Biorender.com. Red arrow in both diagrams showing the unexpected derivation of neutrophils from plasma blasts. https://www.breakingdownbio.com/breakingdownbioblog/malaria-plasmablasts-are-the-real-parasites monthly 0.5 2020-06-04 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1591305571463-0M409EPJJOKB529LC1BO/malaria-transmission-cycle.png Blog - Malaria. Plasmablasts are the real parasites. Malaria life cycle beginning with the mosquito bite, moving through the human liver and red blood cells back to another mosquito. Source: BioRender (2020). Malaria Transmission Cycle. Retrieved from https://app.biorender.com/biorender-templates/t-5e629f969501410088a0156b-malaria-transmission-cycle https://www.breakingdownbio.com/breakingdownbioblog/the-microbiota-gut-brainnbspaxis-you-are-what-you-eat monthly 0.5 2020-06-03 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1591208864651-Z4P77303SHB4F6PXLSBF/gut-brain-axis.png Blog - The microbiota-gut-brain axis: you are what you eat! The Gut-Brain Axis. You are what you eat! Source: BioRender (2020). Gut-Brain-Axis. Retrieved from https://app.biorender.com/biorender-templates/t-5ceff118a992a00035b823d7-gut-brain-axis https://www.breakingdownbio.com/breakingdownbioblog/poised-or-confused-dcs-type-i-interferons-and-the-microbiota monthly 0.5 2020-06-03 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1591138989475-530G9KNA296DE6WHNABF/Screen+Shot+2020-06-02+at+4.01.14+PM.png Blog - Poised or Confused? DCs, Type I interferons, and the microbiota Microbiota educate dendritic cells via Type 1 interferons in Schaupp et al (2020). https://www.breakingdownbio.com/breakingdownbioblog/the-healing-power-of-poop-fecal-microbiota-transplant-in-ulcerative-colitis-patients monthly 0.5 2020-06-02 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1590890457676-0RHQY0EKV3OQMUIP003V/Screen+Shot+2020-05-30+at+6.59.26+PM.png Blog - The Healing Power of Poop: Fecal Microbiota Transplant in Ulcerative Colitis Patients Graphic from Leonardi et al describing their findings. https://www.breakingdownbio.com/breakingdownbioblog/connection-established-missing-linker-between-intracellular-pathogen-detection-and-inflammationnbsp monthly 0.5 2020-05-20 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1589931467970-PXKZT8EIKC2EKF4KZO08/Screen+Shot+2020-05-19+at+4.24.09+PM.png Blog - Connection established: Missing linker between intracellular pathogen detection and inflammation.  Schematic of SLC15A4- and TASL-dependent IRF5 activation by TLR7, TLR8 and TLR9 from the primary paper, Heinz et al. https://www.breakingdownbio.com/breakingdownbioblog/float-on-a-modest-mouse-for-covid-19 monthly 0.5 2020-05-20 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1589820661090-KW376VT0GSTEQHZ6LXGG/Picture1.png Blog - Float On: A Modest Mouse for COVID-19 Advertisement for the hACE2 transgenic mouse from Jackson labs https://www.breakingdownbio.com/breakingdownbioblog/a-hostile-takeover-tumors-can-program-t-cells-to-express-pd-l1-and-restrain-their-antitumor-responses monthly 0.5 2020-05-20 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1589587065413-ILFUM205KUCH90MZ0NU3/headshot.jpg Blog - A hostile takeover: Tumors can program T cells to express PD-L1 and restrain their antitumor responses https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1589585384227-S0BKTHQE53Q3EI8DGWL0/Screen+Shot+2020-05-15+at+4.29.21+PM.png Blog - A hostile takeover: Tumors can program T cells to express PD-L1 and restrain their antitumor responses Figure 1. PD-1/PD-L1 interactions. A. Tumor cells upregulate PD-L1, which binds to PD-1 on T cells and suppresses their activity. B. PD-1 and PD-L1 checkpoint inhibitor drugs bind to the surface of these proteins, thereby blocking their interaction and preventing T cell suppression. T cells are then able to mount antitumor responses. https://www.breakingdownbio.com/breakingdownbioblog/scrna-seq-going-viral-using-sequencing-technologies-to-understand-the-severity-of-covid-19-patients monthly 0.5 2020-05-20 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1589494754887-41FV47GLYE20Z0B4H13S/SARS-CoV-2+schematic.png Blog - ScRNA-seq going viral: using sequencing technologies to understand the severity of COVID-19 patients The ACE2 receptor on lung epithelial cells, from Anthony Venida’s earlier post. https://www.breakingdownbio.com/breakingdownbioblog/better-latent-than-never-common-infections-may-allow-hiv-to-persist monthly 0.5 2020-05-14 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1589431773085-XZ9TSEPBH9DNYQAH3VG1/HIV+NIH-NIAID.jpg Blog - It’s not better latent than never: common infections may allow HIV to persist Schema describing the molecular events of HIV infection, reproduced from the NIAID-NIH website. https://www.niaid.nih.gov/diseases-conditions/hiv-replication-cycle https://www.breakingdownbio.com/breakingdownbioblog/ingenuity-of-a-miniscule-to-savage-the-cerebral-titan-how-did-the-coronavirus-disrupt-modern-society monthly 0.5 2020-05-13 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1589310485980-0TMC0EN2HX71VFU0SKEP/Picture1.png Blog - Ingenuity of a miniscule to savage the cerebral titan: how did the coronavirus disrupt modern society? - “One general law, leading to the advancement of all organic beings, namely, multiply, vary, let the strongest live and the weakest die.” ― Charles Darwin, The Origin of Species “One general law, leading to the advancement of all organic beings, namely, multiply, vary, let the strongest live and the weakest die.” ― Charles Darwin, The Origin of Species https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1589314085808-N1OBPIKA7E083K04KKY7/navchetan_headshot1-sm.jpg Blog - Ingenuity of a miniscule to savage the cerebral titan: how did the coronavirus disrupt modern society? - Written by Navvy Kaur Immunologist, Informatician, trying to learn some machine learning and grasp few mathematical concepts. Written by Navvy Kaur Immunologist, Informatician, trying to learn some machine learning and grasp few mathematical concepts. https://www.breakingdownbio.com/breakingdownbioblog/spike-and-block-the-search-for-a-sars-cov-2-antibody-treatment monthly 0.5 2020-05-08 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1588891247947-YB40QX3SJ0YYVL6K5N10/Screen+Shot+2020-05-07+at+3.40.21+PM.png Blog - Spike and block: The search for a SARS-CoV-2 antibody treatment The spike protein helps the virus infect human cells; therefore, it is a major target of antibody-based strategies to neutralize the virus. https://www.breakingdownbio.com/breakingdownbioblog/the-enemy-of-my-enemy-is-my-friend-bacteria-and-bacteriophages monthly 0.5 2020-05-08 https://www.breakingdownbio.com/breakingdownbioblog/who-wants-seconds-the-gut-bacteria-derived-secondary-bile-acid-isodca-induces-regulatory-t-cells monthly 0.5 2020-05-08 https://www.breakingdownbio.com/breakingdownbioblog/small-smaller-smallest-is-aerosol-transmission-possible-for-sars-cov-2 monthly 0.5 2020-05-08 https://images.squarespace-cdn.com/content/v1/5e8bb2b1db0f0c5f7fb75e66/1588265862277-0O3NRC3LSN98EQ59AC5W/Screen+Shot+2020-04-30+at+9.57.30+AM.png Blog - Small, smaller, smallest: is aerosol transmission possible for SARS-CoV-2? Can SARS-CoV-2 be detected in the smallest particles, called aerosols? Yes says a new paper from Ke Lan’s lab at Wuhan University, which has implications for even more rigorous cleaning protocols. https://www.breakingdownbio.com/breakingdownbioblog/are-macrophages-a-lymphocyte-frenemy-covid-19-post-3 monthly 0.5 2020-05-08 https://www.breakingdownbio.com/breakingdownbioblog/rys4vt11s33sew6qq52pghq55pa25x monthly 0.5 2020-05-08 https://www.breakingdownbio.com/breakingdownbioblog/how-do-we-know-sars-cov-2-wasnt-man-made monthly 0.5 2020-04-24 https://www.breakingdownbio.com/breakingdownbioblog/tag/plasmablasts monthly 0.5 https://www.breakingdownbio.com/breakingdownbioblog/tag/Tcells monthly 0.5 https://www.breakingdownbio.com/breakingdownbioblog/tag/CD8%2B monthly 0.5 https://www.breakingdownbio.com/breakingdownbioblog/tag/IGF1R monthly 0.5 https://www.breakingdownbio.com/breakingdownbioblog/tag/COVID-19 monthly 0.5 https://www.breakingdownbio.com/breakingdownbioblog/tag/Neuropilin-1 monthly 0.5 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